Abstract

Objective: To find the correlation between urinary Retinol-Binding Protein 4(RBP-4) and renal function in Type 2 Diabetics.
Methodology: Study included 60 type 2 diabetics. 20 normal subjects were taken as control. Level of blood glucose, glycosylated hemoglobin, serum creatinine, and RBP-4 were estimated in both patients and control subjects.
Results: Mean age in patients and controls was in a range of 45- 47 years with a mild increase in BMI. Levels of HbA1c and of RBP-4 were significantly high in patients compared to controls. Levels of serum creatinine were non-significantly increased in patients as compared to controls. A significant negative correlation of RBP-4 with serum creatinine was also observed. Positive correlation was observed between age and HbA1c with RBP-4.
Conclusion: Urinary RBP-4 may be an early marker of diabetic nephropathy in diabetic subjects and may be used as a tool for monitoring the disease.

Key words: Retinol binding protein 4, serum creatinine, diabetic nephropathy.