Manganese (Mn) is an essential trace metal and acts as cofactor in many cellular enzymes. But excessive concentration
of the Mn is potentially toxic resulting in several disorders. Astaxanthin is a potent antioxidant with anti-inflammatory activity ,The
present study was designed to evaluate the role of Astaxanthin in disorder causes by toxic effects of manganese chloride (MnCl2
.4H2 O) exposure on marker biochemical parameters, of thyroid gland and enzymatic antioxidant (Superoxide dismutase enzyme
SOD, Catalase CAT , Glutathione GSH and Malondialdehyde MDA) in rats. Adult male rats were randomly divided into three
groups. In group 1, the rats were treated with vehicle (1 ml distill water) and served as control. The rats in group 2 were treated
with MnCl2(50 mg/kg b.wt./day)and Astaxanthin 50 mg/kg b.wt./day) for 30 days The results showed Serum levels of The thyroid
hormones, 3,5,3′-triiodotyronine (T3) , and its precursor, namely the “prohormone” thyroxine (T4), significantly decreased in group
2 which treated with MnCl2, and thyroid stimulating hormone TSH increased but normal level T3,T4,TSH in G3 , and thyroid
stimulating hormone TSH increased but normal level T3,T4,TSH in G3 . The results showed Serum levels of The (SOD,CAT,
GSH) significantly decreased and while MDA increase in group 2 which treated with MnCl2 and Serum levels of The (SOD,CAT,
GSH significantly increased and while MDA decrease in group 3 which treated with MnCl2+Astaxanthin. Taken this data suggest
that MnCl2 exposure has adverse impact on the functions of thyroid gland, antioxidant level in serum and astaxanthin reduces the
damage of thyroid gland caused by MnCl2 and scavenge free radicls by disrupting free-radical chain reaction.
Key words: Astaxanthin , manganese chloride ,antioxidants , T3,T4.
|
