Objective: This study was mainly designed to solve the drawback of conventional Nebivolol solid dosage form, low
bioavailability and limited clinical efficacy, by preparing Solid dispersion. Methods: Nebivolol solid dispersionwas developed by
kneading method to modify the release and enhance solubility of the drug. The physical state of the dispersed Nebivolol in the
polymer matrix was characterized by differential scanning calorimetry, powder X-ray diffraction, scanning electron microscopy,
Fourier-transform infrared spectroscopy, super saturation solubility testing and dissolution studies. Optimized Nebivolol solid
dispersions were formulated into tablets by direct compression method. Results: Compared with pure drug and physical mixture,
the dissolution of Nebivolol - Solid dispersion was enhanced dramatically. Optimized Nebivolol solid dispersions tablet showed
faster drug release in comparison to marketed tablet. Optimized formulation follows Higuchi’s equation and the release mechanism
is super case II transport. Conclusion: The present study conclusively indicated that the use of solid dispersion method by using
water soluble carriers improved the solubility of poorly water soluble drug.
Key words: Solid dispersion, Nebivolol, Tablets, Optimization, Solubility enhancement.
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