Abstract

Aim: In this study, it was aimed to examine the serum levels of dopamine, oxytocin, and butyrylcholinesterase (BchE) enzyme activity in advanced Alzheimer's patients (AD).
Material and Method: For our preliminary study, a total of 40 participants were included in the study. 20 of the participants consisted of patients and the other 20 made up the control group. In the serum samples of the patient and control group, the levels of dopamine and oxytocin were measured by Enzyme-Linked ImmunoSorbent Assay (ELISA) method, while the BchE activity was measured by the spectrophotometric method.
Results: We found that serum BchE and oxytocin levels in the AD group were statistically lower than the controls (p0.05).
Conclusion: Our results indicate that the decrease in BchE activity and oxytocin levels and the increase in dopamine levels may have a relationship with the progression of the disease in the AD group. However, we believe that studies are needed with larger numbers of
patients with different levels of AD.

Key words: Alzheimer; dopamine; oxytocin; butyrylcholinesterase