Home|Journals|Articles by Year Follow on Twitter

Directory for Medical Articles

Open Access

Original Research

Adverse drug reaction monitoring of antitubercular drugs during intensive phase at tertiary care medical college hospital: A prospective study

Manju Ramakrishnan, Nisha Maheshwari Y, Ezhil Ramya J, Krishnamoorthy K.

Background: Tuberculosis (TB) an infectious disease can cause serious economic burden to the country and to the patients. About quarter of the world TB cases are reported in India. As many newer and newer drugs emerge it creates newer and rare side effects which may lead to the discontinuation of the drug and finally end up in multi-drug resistant TB. Hence, monitoring of these related adverse drug reactions (ADRs) is very essential wherein the drug causing ADR can be detected and appropriate therapeutic regimen can be tailored to the patient and thus reduce the economic burden.

Aim and Objective: The aim of the study was to assess the rate of prevalence of ADR with antitubercular drugs during intensive phase of treatment in Tirunelveli Medical College Hospital (TVMCH).

Materials and Methods: The sample size of 100 patients who were diagnosed with pulmonary TB and undergoing treatment in TVMCH was observed for any adverse effects. The observed adverse effects were recorded using “Adverse Drug Reactions reporting form.” The casualty and the severity assessment were done using WHO-Uppsala Monitoring Centre Criteria and Hartwig-Siegel Scale, respectively.

Results: Among 100 pulmonary TB patients receiving fixed-dose combination pills the most commonly observed adverse effects are Nausea (20 cases), hepatitis (19 cases), gastritis (15 cases), and other side effects such as pruritus, abdominal cramps, and diarrhea.

Conclusion: Early identification, reporting, and management of ADRs remain key factors in the treatment of a newly diagnosed TB patients. It can be revised even more to lower the severity levels and achieve elimination of TB.

Key words: Adverse Effects; Casualty Assessment; Severity Assessment; Hartwig-Siegel Scale; WHO- Uppsala Monitoring Centre criteria

Similar Articles

In vitro and in silico anti-osteoporosis activities and underlying mechanisms of a fructan, ABW90-1, from Achyranthes bidentate.
Li T, Hou X, Huang Y, Wang C, Chen H, Yan C
Carbohydrate polymers. 2022; 276(): 118730

Effects of selenium-containing compounds on Cu/Zn-induced neuronal cell death and potential application as therapeutic agents for neurological diseases.
Tanaka KI, Shimoda M, Kawahara M
Neural regeneration research. 2022; 17(2): 311-312

Relative power: Explaining the effects of food and cash transfers on allocative behaviour in rural Nepalese households.
Harris-Fry H, Saville NM, Paudel P, Manandhar DS, Cortina-Borja M, Skordis J
Journal of development economics. 2022; 154(): 102784

Health technology assessment and economic evaluation: Is it applicable for the traditional medicine?
Chen Y
Integrative medicine research. 2022; 11(1): 100756

Chemometric analysis of the global pattern of volatile organic compounds in the exhaled breath of patients with COVID-19, post-COVID and healthy subjects. Proof of concept for post-COVID assessment.
Zamora-Mendoza BN, DĂ­az de LeĂłn-MartĂ­nez L, RodrĂ­guez-Aguilar M, Mizaikoff B, Flores-RamĂ­rez R
Talanta. 2022; 236(): 122832

Full-text options

Latest Statistics about COVID-19
• pubstat.org

Add your Article(s) to Indexes
• citeindex.org

Covid-19 Trends and Statistics
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright © ScopeMed® Information Services.

ScopeMed Web Sites