Bone mineral density (BMD), and bone-relate marker measurements in elders are necessary to providing for osteoporosis diagnosis and can be predict supplement effectiveness. This study was aimed to evaluate and compare the effectiveness of short-term calcium and vitamin D supplements in normal and osteoporotic elders. The cross sectional study was determined BMD; bone turnover markers (BTMs) including procollagen type 1 N-terminal propeptide (P1NP), osteocalcin (OC), beta-crossLaps (CTX) and alkaline phosphatase (ALP); 25-hydroxy-calciferol [25-(OH)D]; and bone-related minerals in normal group (N = 30) and in osteoporotic elders (N = 30) before and after calcium and vitamin D3 supplements daily for three months. BMD was measured by calcaneal quantitative ultrasound (QUS). Serum concentrations of bone-related biochemical markers were determined by automatic analyzers. Paired t-test was used for statistical analysis. BMD of both groups before and after supplementation were significantly increased. In normal group, phosphorus, ALP, and P1NP were significantly increased (p
Key words: osteoporosis, bone mineral density (BMD), bone turnover markers (BTMs), calcium and vitamin D supplement, bone-relate biomarkers
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