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Evaluation of anti-diabetic and anti-inflammatory activities of Fenugreek (Trigonella foenum-graecum) seed extracts on Albino Wistar Rats

Venkatnarayana Narapogu, Swathi C, Madhukar Rao Polsani, John Premendran.


Background: Fenugreek (Trigonella Foenum-Graecum) is a compound used since ancient times in Indian folk medicine for several medicinal properties. It has been known to produce hypoglycemic and antioxidant actions.

Aim and Objective: This
study aimed to determine ethanolic extracts out of fenugreek seeds for the anti-diabetic including anti-inflammatory effects on Wister rats.

Materials and Methods: Inbred Albino male and female Wistar rats were used for the study. The powdered seeds were extracted with 90% ethanol by Soxhelation (100 g) for 3–4 days. The diabetes was assessed after 72 h of alloxan-induced to rats by determining the blood sugar level. Rat Paw volume was measured to the ankle joint in drug-treated and untreated groups at 0 min, 30 min, 60 min, and 120 mins using carrageenan challenge measured mercury plethysmograph.

Results: Fenugreek at 200 mg/kg dose and 400 mg/kg decreased blood glucose which was dose-dependent. The reductions in blood glucose levels (BGLs) were significant post 14th day in both groups. The antiinflammatory activity Fenugreek 200 mg/kg did not significantly reduce paw volume. Fenugreek at the dose of 400 mg/kg demonstrated inhibition of paw volume to 39.076% at the end of 2 h which was lesser than standard drug Aspirin.

Conclusion: T. foenum-graecum decreased blood glucose towards the end of 21 days reduced the BGLs like the standard drug Gliclazide. The anti-inflammatory actions of the extracts were not found to be significant at the dose of 200 mg/kg and moderate anti-inflammatory actions at the dose of 400 mg/kg compared to standard drug Aspirin.

Key words: Fenugreek; Trigonella foenum-graecum; Anti-diabetic; Anti-inflammatory; Ethanolic extracts

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