Schizophrenia is a serious neuropsychiatric disorder that affects 1% of the world's population. It plays an important role in psychiatric symptoms, including major depression and schizophrenia. However, it is also known that one of the main reasons underlying the pathogenesis of schizophrenia is oxidative stress. Transcranial direct current stimulation (tDCS) has recently been a promising method for modifying neuronal membrane stimulation, cognition, and behavioral function. Our aim in this study is to explore the effects of 0.5 mA anodal tDCS stimulation on schizophrenia-like behaviors and oxidative stress in a ketamine-induced schizophrenia model. 30 male Balb/C mice were divided into 3 groups as control, schizophrenia, and schizophrenia+tDCS. The schizophrenia model was created by administering 25mg/kg/day ketamine for 7 days. tDCS treatment was performed by giving 0.5 mA anodal tDCS stimulation for 7 days. On day 14 of the experiment, SCZ-like behaviors were assessed using a novel object recognition test (NOR), open field test (OF), and tail suspension test (TST), and also oxidative stress in hippocampus and prefrontal tissues was estimated. Results showed that locomotor activity, depressive and anxiety-like behaviors of the schizophrenia group increased significantly compared to the control group and decreased after tDCS stimulation (p
Key words: tDCS, Schizophrenia, Oxidative Stress
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