Biodegradable and non-toxic poly[bis(p-oxy azo benzoic acid diethylamino)
phosphazenes] (POABADEAP) was synthesized in two steps. In first step, the
polydichlorophosphazenes (PDCP) was synthesized from
hexachlorocyclotriphosphazene (HCCP) by thermal ring opening polymerization
in the presence of AlCl3 as catalyst and in second step chlorines from PDCP were
substituted by hydroxy groups of p-hydroxy azobenzoic acid and then
diethylamine respectively. The synthesis results were proved by 1H NMR and
GPC. Hydrolytic degradation of POABADEAP was studies and it was found that
polymer degraded smoothly for the biomedical application such as drugs
delivery and for social benefits of human beings.
Key words: Polyphosphazenes, synthesis, characteristics, azobenzene, biomedical
applications, drugs delivery, hydrolytic degradation, Social Benefit
|
