Diabetic nephropathy (DN) is a long-term complication of diabetes mellitus. The characteristic of early-stage DN is glomerular hyperfiltration that has been linked to renal fibrosis. In the present study, we investigated the effect of Moringa oleifera (M. oleifera) leaf extract on DN in streptozotocin (STZ)-induced diabetic nephropathy rats. Rats were injected with 50 mg/kg STZ to establish the DN model. Four weeks after receiving an injection of STZ, DN rats were administered distilled water, M. oleifera leaf extract (100 or 200 mg/kg body weight/day), dapagliflozin (1 mg/kg body weight/day) or combinations of these for a further 8 weeks. DN rats exhibited significantly increased blood glucose (504.00±28.41 mg/dL), proteinuria (192.85±41.23 mg/24 h), albuminuria (6.68±1.54 mg/24 h), BUN (47.14±5.18 mg/dL) and creatinine clearance (5.64±.35 ml/min) (p
Key words: Diabetic nephropathy, Moringa oleifera, Streptozotocin, Renal fibrosis, Renal hyperfiltration, Oxidative stress
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