Objective: This study aimed to investigate oxidative metabolism and oxidative DNA damage in the state of euthymic and active disease in patients with Bipolar disorder (BD).
Methods: 40 active (26 mania and14 depression episodes) and 40 euthymic state of disease of the 80 patients with BD and 48 healthy volunteers were included to the study. Measurement of the levels of serum total antioxidant (TAS) and serum total oxidant (TOS), Oxidative Stress Index (OSI), and 8-hydroxy-2-deoxyguanosine (8-OHdG) levels were calculated and evaluated. Hamilton Depression Rating Scale (HAM-D), Young Mania Rating Scale (YMRS) and Clinical Global Impression Scale (CGI) were administered.
Results: In patients with BD, TAS, TOS, OSI, and 8-OHdG levels were significantly higher than controls (all p
Key words: Bipolar disorder, oxidative stress, level of total antioxidant, level of total oxidant, oxidative DNA damage, 8-hydroxydeoxyguanosine.
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