Abstract

Stevens-Johnson syndrome (SJS) and Toxic epidermal necrolysis (TEN) are serious dermatological reactions. Combination of Spironolactone and Torsemide is used to treat various oedemas. When used alone or in combination, Torsemide and Spironolactone can rarely cause Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), which has been reported in various post-marketing surveys. This case report gives details of a 58 year old female patient who developed multiple, erythematous to hyperpigmented papules; some having erythema multiforme like morphology and few vesicles and bullae over various parts of body following the use of the fixed dose combination of Torsemide (10mg) + Spironolactone (50mg) to treat ascites of autoimmune hepatitis. The patient was diagnosed to have developed Spironolactone + Torsemide induced Stevens-Johnson Syndrome. This case report adds and increases need for awareness of rare but serious side effects of Torsemide and Spironolactone. The report emphasizes on active monitoring of drugs use for to prevent harm from the serious side effects like SJS.

Key words: Torsemide, Spironolactone, Stevens-Johnson Syndrome