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Original Research

RMJ. 2023; 48(4): 1061-1064


Melatonin attenuates drug induced liver injury caused by combined effect of methotrexate and isoniazid

Aamna Khokhar, Sadia Shaukat, Zunera Hakim, Aisha Qayyum, Saima Rafique, Abeera Sikandar.




Abstract

Objective: To investigate the shielding effect of melatonin in drug induced liver injury (DILI) by isoniazid (INH) and methotrexate (MTX).
Methodology: This experimental study was performed at Department of Pharmacology, Army Medical College, Rawalpindi from November 2015 to November 2016. Thirty-six Balb/c male mice were split into 6 groups (n=6). Two groups (A1 and A2) served as controls for MTX and INH treated mice. Group B and C received MTX and INH, respectively. Group D received INH and MTX. Group E received INH and MTX along with melatonin. Serum liver enzymes and liver histological slides were taken after 24 hours of last dose.
Results: Serum liver enzymes were significantly elevated in group B (MTX) and in group D (MTX + INH) (p

Key words: DILI, isoniazid, melatonin, methotrexate.






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