Home|Journals|Articles by Year

Directory for Medical Articles

Open Access

Original Article

Synthesis, preliminary anticonvulsant and toxicity screening of substituted {1-[4-Methyl-2-substitutedphenyl-2,5-dihydro-1,5- benzothiazepin-3-yl]-ethylidene}-hydrazine

Vikash Kumar Chaudhri, Devender Pathak, Zeashan Hussain.

1,5-benzothiazepine moiety is a very important pharmacophore bioactive compound that exhibits different biological activities. The basic constituent of benzodiazepine nucleus is diltiazem. 1,5-benzothiazepine nucleus shows different potential biological activities in various field. Our research mainly focuses on synthesis of new substituted benzodiazepine nucleus which retained anticonvulsant biological activities with less toxic effect. We synthesized successfully various substituted {1-[4-Methyl-2-substitutedphenyl-2,5-dihydro-1,5-benzothiazepin-3-yl]-ethylidene}- hydrazine (6a–6j) and chemical structures confirmed by chromatographic, electro analytical, and physiochemical methods. The preliminary screening of novel synthesized compounds anticonvulsant activity by maximal electroshock model. Based on anticonvulsant screening result, the most potent derivative was found 6c. Furthermore, preliminary safety profile of most active compound 6c was evaluated by the neurotoxicity and acute oral toxicity testing.

Key words: Acute toxicity; Anticonvulsant; Neurotoxicity; Schiff’s bases

Similar Articles

Full-text options

Latest Statistics about COVID-19
• pubstat.org

Add your Article(s) to Indexes
• citeindex.org

Journal Finder
Covid-19 Trends and Statistics
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.