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RMJ. 2006; 31(1): 10-13

Inverse Association of Serum Leptin with Serum C-reactive protein (CRP) in Regular Hemodialysis Patients.

Hamid Nasri, Azar Baradaran.


Objective: To elucidate whether and how in patients with uremia on hemodialysis
the level of CRP as the marker of inflammation correlate with serum leptin.
Patients and Methods: Serum leptin and CRP were determined on patients with
ESRD on hemodialysis
Results: The total patients were 36 (f =15, m=21). The mean patient's age were 46
(±16) years. The median length of the time patients had received hemodialysis was
19 months. The mean serum CRP was 8.7±6.6 mg/L. The mean serum leptin was
9.4±14 ng/ml.
Conclusion: We found a significant inverse correlation of serum leptin with serum
CRP (r= -0.57, p = 0.041). Our data supports the hypothesis that in patients on
hemodialysis, the association of leptin with CRP levels was inverse which could
show the positive effects of leptin on nutrition and support the theory of protective
effects (reverse epidemiology) of leptin in hemodialysis patients.(Rawal Med J

Key words: Hemodialysis, End-stage renal failure, Leptin, C-reactive protein(CRP)

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