An efficient Hantzsch four-component condensation reaction for the synthesis of polyhydroquinolines was found to proceed in the presence
of L-proline in ethanol at room temperature. The method is really simple and environmentally benign. The keys features of this protocol are
the use of a bio, organic and reusable catalyst, high yields of products, using nontoxic solvent and short reaction times from the principles
of green chemistry point of view.
Key words: Synthesis; Polyhydroquin‾ L-pr‾ Catalyst; Four components
|
