Abstract

The aim of this study was to find the dynamic of ultrastructural changes of liver at CS and the role of PRP-1 (proline rich peptide) as a
protector. Our investigation demonstrated that Mch (mitochondria) of brain are more subject to changes at 2 h of compression than liver
Mch, but one time administration of the PRP-1 in a dosage of 10 g/100 g of the animal weight before decompression period prevent the
development of the destructive changes of the hepatocytes of the liver and neurons of the rat cortex (injection of PRP on the background of
CS prevent progress of ultrastructural changes typical at 4 h of decompression, and leads to Mch fission).

Key words: Crush syndrome, PRP-1, TEM, neurone, hepatocyte, mitochondria (Mch).