New series of N-[3-(2-amino-5-nitrothiazolyl)-propyl]-4-(substitutedphenyl)-3-chloro-2-oxo-1-azetidine-carboxamide, compounds 4a-4j
have been synthesized and characterized by chemical and spectral analyses such as IR, 1H NMR, 13C NMR and FAB-Mass. All the
synthesized compounds 4a-4j were screened for their antibacterial and antifungal activities against some selected bacteria and fungi with
their MIC values and antitubercular activity screened against M. tuberculosis. Anti-inflammatory activity was in vivo screened against
albino rats. Some compounds of the series showed good activities.
Key words: Synthesis, 2-amino-5-nitrothiazole, azetidinone, antimicrobial, antitubercular, antiinflammatory.
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