Saurauia vulcani flora develops certainly in North Sumatra Province, Indonesia. It is normally consumed as an antidiabetic remedy and a treatment related to digestion diseases. This research aims to isolate the major compound from S. vulcani plants and assess the bioactivity of the S. vulcani plant for its anti-colorectal cancer potential. Subsequently, the ethyl acetate fraction was analyzed with a solvent system used as the eluent ethyl acetate: methanol: Aquadest = 4.6:0.2:0.2. Utilizing spectroscopy, we determined the chemical structure of the remote substance. Utilizing the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide technique in vitro, the anti-colorectal cancer activity was demonstrated against WiDr cancer cells. This study revealed that the major compound was identified as avicularin. The avicularin compound is a flavonoid group known to have anticancer activity. The cytotoxicity of avicularin compound was assessed against the WiDr cell line, with a 50% inhibition concentration value of 521.14 μg/ml. The bioactivity of the ethyl acetate fraction is stronger than that of the isolated part (avicularin compound).
Key words: Saurauia vulcani, plant leaves, extract, colorectal cancer, avicularin
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