Home|Journals|Articles by Year|Audio Abstracts
 

Original Article

Open Vet J. 2020; 10(1): 94-115


Genomic Characteristics of Classical Swine Fever Virus Strains of Bovine Origin According to Primary and Secondary Sequence Structure Analysis

Massimo Giangaspero,Shu Qin ZHANG.




Abstract
Cited by 2 Articles

Classical swine fever virus (CSFV), species member of the family Flaviviridae, is generally considered restricted to domestic and wild suids. Circulation of CFSV has been detected in cattle herds in China and India. Natural infection appeared associated with clinical signs in some cases. Secondary structures of the internal ribosome entry site (IRES) in the 5’ untranslated region (UTR) were used for genomic characterization. Sequences have been compared to representative CSFV strains isolated from pigs, vaccines and contaminants from porcine cell lines and an ovine strain isolated in Spain. Observed sequences from cattle showed genetic relatedness with live attenuated vaccine strains used in pigs. Sequence characteristics of the Chinese strain S171 resulted genetically distant from previously reported CSFV genotypes, suggesting a new outgroup in the species, described for the first time and named CSFV-d. Other Chinese strains were genetically closely related to CSFV genotype a2 (Alfort type) pig strains. Indian strains, reported from the states of Tamil Nadu and Meghalaya, were genetically closely related to CSFV genotype a1 (Brescia type) and a5 pig strains, respectively. These preliminary observations are new and relevant in countries where CSFV control and eradication strategies are applied.

Key words: Cattle, Classical swine fever virus, Pestivirus, Secondary structure.






Full-text options


Share this Article


Online Article Submission
• ejmanager.com




ejPort - eJManager.com
Refer & Earn
JournalList
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under Creative Commons Attribution 4.0 International License (CC BY), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.