Objectives: To compare the effect of on-pump and off-pump CABG on the induction of the
oxidative stress and the metabolism of homocysteine, which is involved in the synthesis of
glutathione.
Methods: This retrospective study was performed in Shahid Madani Heart Hospital in Tabriz, Iran
in 2004 using a questionnaire. Plasma homocysteine, folate total antioxidant capacity (TAC) and
malonedialdehyde (MDA) were determined on blood samples obtained from 40 patients undergoing
CABG, preoperatively and at 0,12,48,120 hours and 6 months after surgery. The patients were
divided into two matched groups, one off-pump and the other on-pump CABG.
Results: A marked reduction of homocysteine, folate and significant elevation of MDA were
noticed at 0, 12, 48 hours after operation in the both groups (P
Key words: CABG, CPB, homocyctein, folate,oxidative stress.
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