A comparative study of lipid profile among non-diabetic offspring of diabetic and non-diabetic parents – It’s role as early indicator of atherogenesis and a trigger for pacing pathophysiological changes in the future development of peripheral arterial disease
Seema Shridhar Sankeshwari, Khararashah F Kammar, Vijayashri Basavaraj Hanchinal.
Background: International Diabetes Federation estimated that India has more diabetic patients 74 million than any other country of the world after China 121 million. Family history of the first-degree relatives being a traditional risk factor, parental-specific transmission of risk alleles to offspring often associated with DNA methylation and imprinting.
Aims and Objectives: The aim of the study was to assess the genetic role of lipid profile as an early indicator of atherogenesis and peripheral arterial disease (PAD) onset and to provide necessary interventional/preventional measures.
Materials and Methods: Taking all inclusion and exclusion criteria into consideration, 50 offsprings of diagnosed diabetic parents (>5 years) were taken as cases, and 50 healthy age-matched offsprings were taken from non-diabetic parents as controls. A thorough physical and systemic examination was done. After getting informed written consent, anthropometric measurements and fasting blood sample were collected for cholesterol (C), triglycerides (TGs), high-density lipoprotein, and low-density lipoprotein. Statistical analysis was done by Student’s t-test in SPSS software.
Results: The mean values for cholesterol (mg/dl) were 169 ± 24.95 in controls and 193 ± 28.10 in cases with P = 0.0001. Simultaneously, mean values for TG (mg/dl) were 132 ± 37.95 for controls and 155.2 ± 58.1 for cases with P = 0.0240 (significant).
Conclusion: Although anthropometric measurements did not show any statistically significant variations, significant values of cholesterol and TG cannot be ignored. By keeping the view of genetic history of Type 2 diabetic parents, the future advice for a regular Doppler studies along with low dose of statin drugs to prolong the possible atherogenesis complications can be given.
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