Bipolar disorder is characterized by recurrent mood episodes and its pathophysiology remains a mystery. Inflammation is thought to be core feature in pathophysiology of bipolar disorder. The aim of this study is to compare neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), monocyte/lymphocyte ratio (MLR) and mean platelet volume (MPV) as systemic inflammatory markers between different mood episodes in same patients and healthy controls, to evaluate whether these may serve as a possible trait or state biomarker of bipolar disorder. This retrospective study was performed on 127 patients and 98 healthy controls. Among the patients, only 27 presented euthymia, mania, and depression, 89 presented mania and euthymia, 47 presented mania and depression and 45 presented depression and euthymia at different times. This study indicated that NLR and MLR values in mania were higher than in euthymia of same patients (p=0.014, p=0.023). Additionally, we found that patients in mania had higher levels of MPV, NLR and MLR than controls (p=0.015, p=0.030, p=0.045). Our results support the association of bipolar disorder with systemic inflammation and suggest that NLR and MLR may be potential state biomarkers for in manic episodes.
Key words: Bipolar disorder, neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, monocyte/lymphocyte ratio
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