Bupivacaine hydrochloride is an anesthetic with prolonged duration of action. The aim of this study was to develop a fast, simple and
sensitive spectrophotometric method for the determination of bupivacaine in pharmaceutical preparation. The maxim absorbance was
finding at 262 nm. At the same time, a validation study was conducted for the proposed method, in accordance with the bioanalytical
method validation guidelines. The studied validation characteristics showed that the proposed method can be successfully applied to
pharmaceutical preparations analysis.
Key words: bupivacaine hydrochloride, quantitative assay, UV – Vis spectrophotometry, validation.
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