A series of pyrazolines and pyridines bearing benzofuran moiety (M1-M10) were synthesized for evaluation of their in vitro cytotoxicity against MCF-7 and HepG2 cell lines. Also, in silico drug-likeness study was carried out. The result of the cytotoxicity of M1-M10 showed that some compounds displayed cytotoxic activity against MCF-7 and HepG2 cells. Assessment of in silico drug-likeness study of M1-M10 illustrates that some compounds showed agreement to the Lipinski, Ghose, Veber, Egan and Muegge rules with orally bioavailable.
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