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Pharmacological evaluation of Prosopis ruscifolia extract on lipid profile in hyperglycemic and hyperlipidemic mice

Juan R. Centurión, Elena M. G. Diarte, Antonia Galeano, María S. Soverina, Wilfrido Arrúa, María L. Kennedy, Miguel A. Campuzano-Bublitz.

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Diabetes is a serious chronic pathology, with long-term effects including damage to blood vessels or diabetic dyslipidemia. Diabetic dyslipidemia is characterized by increasing concentrations of low-density triglycerides and lipoproteins and a decrease in high-density lipoproteins HDL-cholesterol (HDL-c). This study aimed to evaluate the effect of Prosopis ruscifolia on lipid profile in albino Swiss mice with hyperglycemia and hyperlipidemia. Hyperglycemia was induced by alloxan and the animals were orally treated with Pr (50, 100, and 200 mg/kg) for 45 days. Hyperlipidemia was induced with tyloxapol and the animals were treated with Pr (50, 100, and 200 mg/kg). In hyperglycemic animals treated with 100 mg/kg, there was a decrease in the concentration of cholesterol, a decrease in the concentration of triglycerides, and an increase in HDL-c at the end of treatment compared to untreated hyperglycemic animals. In mice with hyperlipemia treated with 50 and 100 mg/kg of Pr, serum cholesterol and triglyceride concentration were reduced. HDL-c increased in animals treated with Pr 50, 100, and 200 mg/kg compared to untreated animals. It was observed that the administration of P. ruscifolia in hyperglycemic and hyperlipidemic animals had a favorable effect on the lipid profile.

Key words: lipid profile, glycemia, diabetic dyslipidemia, tyloxapol, alloxan

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