Abstract

Solid lipid nanoparticles (SLNs) has emerged as a remarkable nano-colloidal system for drug delivery. This review presents contemporary information regarding various aspects about SLNs, i.e., SLNs morphology, structural features, preparatory methods and their characterizations. This carrier system allows advancing the therapeutic efficacy of drugs belonging several categories. Present uses of SLNs include cancer therapy, infectious conditions, diabetes, central nervous system (CNS) disorders, cardiovascular (CV) disorders, cosmeceuticals and others. SLNs facilitates improved pharmacokinetics and modify drug releases. The prospect of surface modification, enhanced permeation against various biological barriers, the ability to resist chemical degradation, the possibility of encapsulation of two or more therapeutic agents simultaneously, has gained attention for SLNs universally. Simultaneously, this review emphasis on recent research trends pertaining to this carrier system.

Key words: Solid lipid nanoparticles, Carrier system, Nanomedicine, Biocompatibility, Nanotechnology.