The fruit and cork extracts (CE) of the plant Ficus lacor Buch. Ham. were evaluated for its antidiabetic potential in streptozotocin (STZ)-induced diabetic rats. The extracts of fruit and cork of F. lacor Buch. Ham. were carried out by soxhlation method. Acute toxicity study of both extracts of plant was carried out by using the Organization for Economic Cooperation and Development guidelines 425. Diabetes was induced in Wistar rats weighing between 200 and 250 g using STZ (60 mg/kg intraperitoneal). The diabetic animals were divided into seven experimental groups for further study with five animals in each group. The treatment was given to the animals in the groups with glibenclamide (2 mg/kg p.o.), and fruit and CE (200 and 400 mg/kg p.o., respectively) for 21 days. The estimation of different biochemical parameters like glucose, insulin, glycosylated hemoglobin, cholesterol, triglyceride, high density lipoproteins, low density lipoproteins, very low-density lipoproteins, urea, uric acid, creatinine, aspartate aminotransferase, alanine transaminase, and histopathology study was carried out at the end of the experimental period. The result revealed significant improvement in different biochemical parameters when compared with diabetic control group. The fruit extract of F. lacor Buch. Ham. was found to be more effective than CE.
Key words: Ficus Lacor Buch. Ham., streptozotocin, antidiabetic, insulin, lipid profile, histopathology
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