Objective: To measure and to evaluate the effect of bromocriptine on the concentration
of uric acid in infertile women with hyperprolactinema.
Methods: Sixty infertile women, who had serum prolactin concentration at least twice
the upper limit of normal values participated in this study. Serum prolactin and uric acid
concentrations were measured before and after giving bromocriptine 2.5 mg orally daily.
Results: A significant reduction of serum prolactin level (48.04±24.14 to 12.61±11.79)
was seen after treatment with bromocriptine. Normalization of serum prolactin levels was
achieved in 52 (86.7%) patients. A significant drop of uric acid was noted after treatment
with bromocriptine. Mean serum uric acid concentration of 378.4±29.64 μmmol/L
decreased to 365.88±27.34 μmmol/L after bromocriptine therapy.
Conclusions: Serum uric acid concentration is high in infertile hyperprolactinemic
women. Bromocriptine may have an effect on uric acid excretion, suggesting a
hypouricemuic effect of this drug. (Rawal Med J 2007;32:117-119).
Key words: Prolactin, uric acid, bromocriptin, infertility, hyperprolactinemia.
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