Objective: To evaluate the liver biopsies of patients with chronic viral hepatitis and
autoimmune hepatitis based on age, gender, clinical features with staging and grading
of disease.
Material and Methods: This descriptive study was conducted through case series
and all patients who were positive for HBsAg or HCV Ab or autoimmune hepatitis,
had liver biopsies and were assessed for staging and grading based on scheuer system.
Data were analyzed using SPSS version 13 and chi-square test.
Results: One hundred twenty patients were included in this study with 94 males and
26 females. Forty eight (40%) were HBsAg positive, 58 (48.2%) HCV positive, 16
(13.3%) autoimmune hepatitis and 2 had both B and C hepatitis. There was significant
relation between HCVAb with gender (P:0.00), cirrhosis and age (P:0.006), cirrhosis
and gender (P:0.00), staging of hepatitis with duration of clinical signs (P:0.000) and
grading of disease (P:0.000), frequency of cirrhosis and beginning of clinical signs
2
(P:0.000) and significant relation between incidence of autoimmune hepatitis with
gender.
Conclusion: We suggest all patients with chronic hepatitis diagnosed on clinical signs
and serological markers, undergone liver biopsy and scheuer or other staging and
grading to prevent and decrease progression into the end stage phase. (Rawal Med J
2008;33:91-94).
Key words: Keywords: Viral hepatitis, autoimmune hepatitis, cirrhosis.
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