Background: To assess the effect of fasting plasma glucose (FPG) and two-hour
postprandial plasma glucose (2hpp) levels on glycosylated hemoglobin (HbA1C).
Methods: In this descriptive, cross-sectional study 300 patients were enrolled, assessed,
and followed at Diabetic Center of the University of Medical Science Hamedan, Iran. All
were diagnosed type 1 or 2 Diabetes mellitus. We assessed FPG and 2hpp plasma glucose
at baseline and at every two weeks to one month, as needed. HbA1C was assessed at the
end of study. Results were analyzed by Pierson Covariance and Multiple Regression
methods.
Results: The mean plasma glucose in 3 groups of HbA1C (good to fair) were 148.5±56.80
mg/dl at fasting, and 199.70±53.01 mg/dl at 2 hour after breakfast (2hpp) and mean
concentration of glycosylated hemoglobin were 8.41±1.1percent.
Conclusion: The postprandial plasma glucose had more association to glycosylated
hemoglobin than fasting plasma glucose, therefore, evaluating postprandial plasma
glucose should be a preferred method for glucose monitoring. (Rawal Med J 2008;33:12-
14).
Key words: Diabetes Mellitus, fasting plasma glucose, postprandial plasma glucose,
glycosylated hemoglobin.
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