Background: Urinary tract infections (UTIs) are the most common hospital-acquired infections. Antibiotic susceptibility pattern of uropathogens varies due to inappropriate use of antibiotics. The current trend of antibiotic susceptibility pattern of uropathogens is necessary for appropriate therapy of UTIs.
Aim and Objectives: The aim of the study was to assess the antibiotic sensitivity pattern of urinary pathogens in a tertiary care hospital.
Materials and Methods: This retrospective cross-sectional study was conducted from July 2019 to December 2020 at Kodagu Institute of Medical Sciences, Madikeri. Data were collected retrospectively from records of the microbiology department. Antimicrobial susceptibility was done by KirbyBauer disk diffusion method on MuellerHinton agar using Clinical and Laboratory Standards Institute guidelines.
Results: Of 718 urine samples, 197 samples were positive for the growth of organisms. Escherichia coli (31.47%) was the most common uropathogen isolated followed by Klebsiella species (17.76%). Most uropathogens show sensitivity to nitrofurantoin (79.65%), amikacin (66.2%), and gentamicin (61.1%). E. coli was more susceptible to nitrofurantoin (92.7%) and shows increased resistance to ceftriaxone (82.1%) and ampicillin (78.7%).
Conclusion: E. coli was the primary pathogen to be isolated from urinary sample. Majority of uropathogens were sensitive to nitrofurantoin and injectable antibiotics such as imipenem, meropenem, and amikacin. Most uropathogens show resistance to ampicillin, penicillin, and nalidixic acid. E. coli was more sensitive for nitrofurantoin, amikacin, and gentamicin.
Key words: Antibiotics; Urinary Tract Infections; Nitrofurantoin
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