Thiophene, a five membered heterocycle is considered as biologically important dynamic scaffold that holds wide range of biological
activities. The fruitful application of Cephoxitin as antimicrobial, Thenaldine as anti inflammatory, Ralitrexed as anticancer and Erdosteine
as antioxidant proved the potential of thiophene moiety. Diverse biological response profile has pulled in consideration of many researchers
to investigate this heterocycle to its multiple potential against several activities. This review is complementary to previous reviews and
focuses to review the work reported on antimicrobial activities of thiophene derivatives.
Key words: Thiophene, thienopyrimidine, antibacterial, antifungal, antitubercular, minimum inhibitory concentration.
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