Novel Hg(II) complexes of d10 configuration have been synthesized and characterized by elemental analysis, IR, UV-VIS
spectra and thermal analysis. The analytical and spectral data reveal that the ligands (H2L1
- HL3
) behave as neutral or mono
basic bidentate in nature, coordinating via C=O or C-O and NH or C=N. The harmful effect of Hg-polluted drinking water on
male sex hormones, kidney function as well as oxidative status biomarkers of male rats was investigated. Meanwhile, the
potential protective effects of synthesized complexes and their ligands were studied. Results showed that orally
administration of HgCl2 for 30 days caused a significant disruption of male sex hormones and kidney function. Further, the
level of lipid peroxidation was elevated and activities of antioxidant enzymes were markedly declined in kidney and testes
homogenates. The co-administration of HgCl2 with antipyrine and thiosemicarbazone as well as their complexes for four
weeks led to amelioration in the kidney and testes functions as the levels of male sex hormones and kidney function tests
were recovered. Meanwhile, these compounds showed ameliorative effects on the oxidative status of rats. It can be concluded
that drinking of Hg-polluted water induces oxidative stress pathways that may lead to deterioration in kidney and testes
function. The findings also suggest the curative action of antipyrine and thiosemicarbazone as well as their complexes since
they exhibited the ability to resist the harmful action of mercury and to protect the organs from the action of
Key words: DTA; Hg(II) complexes; IR; male hormones; oxidative status; TGA
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