Objective: To determine the correlation of vitamin- D receptor protein (VDR) and vitamin-D with pre-diabetes.
Methodology: This case control study was conducted at Diabetes and Endocrine clinic of Dow University Hospital from August to December 2019. It included 160 subjects (80 pre-diabetics, 80 controls with mean age of 35.9±10.43, 34.72±12.10 years. The sample size was estimated using open-epi software. Serum vitamin D and VDR protein were determined using sandwich enzyme immunoassay (ELISA). Multi-variate regression analysis was done to evaluate the independent predictors for pre-diabetes. Data were analyzed on SPSS version 17.
Results: VDR protein (OR=1.013, 95% CI=1.024-1.041), IFG (OR=0.992, 95% CI=0.235-1.181), IGT (OR=0.911, 95% CI= 0.243-1.000) remained the strong independent predictor of pre-diabetes in logistic regression model adjusted for clinical and anthropometric parameters.
Conclusion: Vitamin D and VDR could be used as a screening marker and target for pre-diabetes. In the future, this could be used for diabetes mellitus prevention.
Key words: Vitamin-D, Vitamin-D receptor protein, pre-diabetes, normoglycemia.
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