Isolation, characterization, and cytotoxic studies of secondary metabolites from the leaves of Bauhinia foveolata Dalzell: An endemic tree from the Western Ghats, India

Prasanna V. Habbu; Narayan Miskin1; Venkatrao H. Kulkarni; Pradeep Bhat; Arun Joshi; Anant Bhandarkar; Satish Kulkarni; Sheshagiri R. Dixit; Jaishree Vaijanathappa

doi:10.7324/JAPS.2020.103018

J App Pharm Sci. 2020; 10(3): 135-148

doi: 10.7324/JAPS.2020.103018

Isolation, characterization, and cytotoxic studies of secondary metabolites from the leaves of Bauhinia foveolata Dalzell: An endemic tree from the Western Ghats, India

Prasanna V. Habbu, Narayan Miskin1, Venkatrao H. Kulkarni, Pradeep Bhat, Arun Joshi, Anant Bhandarkar, Satish Kulkarni, Sheshagiri R. Dixit, Jaishree Vaijanathappa.

Abstract			Cited by 4 Articles
Bauhinia foveolata Dalzell. is an endemic tree, native to South West India (Western Ghats). 13-Docosenamide was isolated from ethyl acetate fraction and Quercetin (1); Isorhamnetin (2) and Odoratin-7-Glucoside (3) were isolated from butanol fraction of leaves. Their chemical structures were elucidated by extensive spectroscopic analyses, including MS and NMR spectra as well as by comparison with the data reported in the literature. Further all the isolated compounds were analyzed for MTT based cytotoxicity studies on human colon cancer cell lines HT-29 and HCT-15 among all the tested compounds quercetin and odoratin-7-glucoside have shown good cytotoxicity towards the selected cells lines. Key words: Bauhinia foveolata, 13-Docosenamide, flavanoids, Cytotoxicity

Isolation, characterization, and cytotoxic studies of secondary metabolites from the leaves of Bauhinia foveolata Dalzell: An endemic tree from the Western Ghats, India

Abstract