Abstract

The system of microcirculation is the first link that is involved in pathological process at different extremely situations. Stress is followed
with disturbance of microcirculation, development of organs' hypoxia and oxidative stress. The aim of this study is to show the type of
angiogenesis in liver and brain under the influence of chronic variable physical stressors. In this study the influence of different stressors
such as forced swimming inhalation, restraint stress, cold stress, orthostatic shock and food deprivation on the microcirculatory stream of
liver and brain was observed. Investigation of sections of liver and brain yielded proof of changes of microvessels on chronic stress (CS).
Thus CS influences a reorganization of blood vessels of liver and brain and it causes angiogenesis of lever sinusoids and brain capillaries.

Key words: Chronic stress, liver, brain, blood vessel, sprouting and intussusception angiogenesis