Home|Journals|Articles by Year Follow on Twitter

Directory for Medical Articles
 

Open Access

Original Article



Effects of Low Level Laser Therapy (LLLT) on Serum Values of Interleukin 6 (IL-6) in Patients with Periodontitis and Type 2 Diabetes Mellitus (T2DM)

Shefqet Mrasori, Mirjana Popovska, Biljana Rusevska, Mirsad Shkreta, Ardian Selani, Visar Bunjaku.

Abstract
Background: In patients with T2DM, the therapeutic effects of conservative treatment are quite limited, and there is a need for additional therapeutic procedures to achieve the desired satisfactory and solid effect. Low-level laser therapy (LLLT) has an anti-inflammatory effect, and is used to heal lesions. This mechanism is realized through inhibition of lipopolysaccharides (LPS), so it can be used in the treatment of periodontal disease in patients with diabetes. Objective: The aim of this study is to assess the effect of level laser therapy (LLLT) on serum IL-6 values in patients with periodontitis and T2DM. Methods: Patients at age between 35-60 years old, with chronic periodontitis (CH) where the clinical loss of attachment (CAL) was ≥4 mm therefore covering at least 50 % of affected teeth. In this study we included 80 patients, divided into two groups: 40 patients with type 2 diabetes mellitus (2TDM) treated with conservative periodontal treatment supplemented with laser therapy (LLLT), group A, and 40 patients with 2TDM, conservatively treated without LLLT. therapy i.e. group B. The laser light was applied to the gingiva in separate quadrants in 5 sessions for the next five days in a row. Blood samples were taken from all subjects at the first treatment, then in 6 weeks and 3 months after treatment, and interleukin 6 (IL-6) levels were measured. The blood samples in the test tubes remained for about 30 minutes and were then distributed in a biochemical laboratory, where they were centrifuged at 6,000 rpm for 10 minutes. The serum was separated from the test tube and transferred to the eppendorph. All serum samples were stored at -80 C until complete analysis and determination of IL-6, according to the standardized methodology. Results: In group A, on the first examination serum IL-6 levels varies in the interval 11.54 1.11 pg / mL, after 6 weeks of therapy the values range between 11.26 0.77 pg / mL, and after 3 months of therapy levels oscillate at intervals of 11.02 0.67 pg / mL. In group B the findings are similar. At the first examination, the serum IL-6 values were 11.56 0.81 pg / mL, after 6 weeks of therapy ranged from 11.59 0.71 pg / mL, and after 3 months of therapy levels were recorded at intervals. 11.41 0.78 pg /mL. The serum IL-6 value after 6 weeks of therapy in patients in group B for Z = -2.04 and p

Key words: low power laser radiation (LLLT), interleukin 6 (IL-6), serum, periodontitis, type 2 diabetes mellitus (T2DM).



Similar Articles

Hyperglycemia in acute ischemic stroke: physiopathological and therapeutic complexity.
Ferrari F, Moretti A, Villa RF
Neural regeneration research. 2022; 17(2): 292-299

Accelerating peripheral nerve regeneration using electrical stimulation of selected power spectral densities.
Yu WM, McCullen MA, Chen VC
Neural regeneration research. 2022; 17(4): 781-782

Wrinkle reduction using a Sasang constitutional medicine-based topical herbal cream in So-eum subjects: A split-face randomized double-blind placebo-controlled study.
Im AR, Ji KY, Nam J, Yoon J, Cha S, Seo YK, Chae S, Kim JY
Integrative medicine research. 2022; 11(1): 100752

Assessment of structural brain changes in patients with type 2 diabetes mellitus using the MRI-based brain atrophy and lesion index.
Zhao H, Wang F, Luo GH, Lei H, Peng F, Ren QP, Chen W, Wu YF, Yin LC, Liu JC, Pan SN
Neural regeneration research. 2022; 17(3): 618-624

Diabetes mellitus and Parkinson's disease: dangerous liaisons between insulin and dopamine.
De Iuliis A, Montinaro E, Fatati G, Plebani M, Colosimo C
Neural regeneration research. 2022; 17(3): 523-533


Full-text options


Latest Statistics about COVID-19
• pubstat.org


Add your Article(s) to Indexes
• citeindex.org






Covid-19 Trends and Statistics
ScopeMed.com
CiteIndex.org
CancerLine
FoodsLine
PhytoMedline
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.



ScopeMed Web Sites