Abstract

We have compared the frequency of thyroid antibodies among diabetic (DM) patients with type 1 and type 2. Diagnosed type-1 DM
patients, having no previous of history were taken as subjects and divided into early adulthood (18 to 35 yrs) and later adulthood (after
35 yrs) groups. Matched subjects with DM type II are taken as controls. In all subjects, serum concentration of free T3 and free T4,
TSH, Thyroid peroxidase antibody (TPO-Ab) and Thyroglobulin antibodies (TG-Ab) were determined. It has been observed that the
serum FT3 levels was lower in type-1 diabetics patients as compared to type II DM. In addition there was a slightly increase in the
values of anti-TPO and anti-TG antibodies in later adult hood of type I DM when compared to the values of early adult hood of type I
DM. And there was significant increase in the values of anti-TPO and anti-TG antibodies in later adulthood of type I DM when compare
to the values of later adulthood of type II DM. It has been suggested that estimation of thyroid antibodies should be done periodically for
every diabetic patients.

Key words: : Diabetes mellitus; serum TSH; serum FT3; serum FT4; anti TPO antibodies; anti TG antibodies