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Original Article

J App Pharm Sci. 2021; 11(7): 158-162

Incidence of nonalcoholic fatty liver diseases and their associated risk factors among the type-2 diabetic population

Usha Sree Puneem, Subburaya Mudaliyar Rajendran Ramakrishnan, Sindgi Vasudeva Murthy, Vanitha Rani Nagasubramanian.

The aim of the study was to investigate the incidence and factors linked with nonalcoholic fatty liver disease (NAFLD) among type-2 diabetes mellitus (T2DM) patients in Warangal, Telangana, India. It was an observational, cohort crosssectional study; a target sample of 100 T2DM patients was recruited from a single study site of Warangal. Detailed medical history was obtained and laboratory examinations and ultrasound imaging were carried out to evaluate the NAFLD. The overall incidence of NAFLD was 80%. The risk of NAFLD was significantly high in subjects with uncontrolled blood glucose levels, abnormal waist circumference, increased aspartate aminotransferase (AST), and elevated triglyceride levels (p < 0.05). In our study subjects, the consumption of alcohol is the predominant risk factor (Odds ratio: 6.652; 95% confident interval: 1.86–23.74 and p = 0.00*) significantly causing NAFLD among the study subjects. Grade-1 and 2 fatty livers are typically associated with elevated AST levels and a high incidence was observed in men.

Key words: Non-alcoholic fatty liver disease; type-2 diabetes mellitus; South India

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