ANGIOTENSIN-CONVERTING ENZYME AND ITS GENE
POLYMORPHISM (I/D) IN ESSENTIAL ARTERIAL
HYPERTENSION
Mohamed A. Taher, Ahmed M. Boghdady, Eman A. Sabet, Usama A. Arafa, Ahmed I. Abd Elneam.
Abstract
The polymorphisms of ACE gene is investigated using polymerase chain reaction for detection of ACE I/D genotype frequency in
hypertensive cases in sector of Egyptian population. Serum ACE is significant higher in hypertensive group than normotensive one (27.5±
4.4 and 21.3± 5.4 ng mL-1
, respectively. Mean SBP (systolic blood pressure), DBP (diastolic blood pressure) and urinary protein excretion
in DD genotype were 181±17 mmHg, 112±19 mmHg, 3.8±0.48 mg mL-1
and 141.5± 36.8 mg day-1
, respectively but in II genotype these
were 142± 10 mmHg, 99± 13 mmHg, 4.35±0.4 mg mL-1
and 116.4± 36 mg day-1
, respectively. In hypertensive patients, serum ACE levels
in DD, ID and II genotypes were 36.2± 5.7, 22.1± 3.7 and 24.5± 4.9 unit ?, respectively. D/D ACE gene polymorphism plays a role in the
development of target organ damage in severe essential hypertension and might have a prognostic value. It can be considered as one of the
risk factor of hypertension.
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