HYDROGEN BONDING AND ACTIVITY ANALYSIS OF
CHOLANE CLASS OF STEROID DERIVATIVES
Sonia Sharma, Rajni Kant.
Abstract
Most of the crystallographic analysis that follows from structure determination involves interpretation of the molecular geometry and a
working knowledge of a variety of intra- and intermolecular interactions based purely on geometrical considerations (distance and angle cut
off criteria). In this paper, a total of fifty-nine structures of cholane derivatives have been chosen for the prediction of their biological
activities and hydrogen bonding interaction analysis. Intermolecular interactions of the type X-H…A [X=C, O, N; A=O, Cl, N, Br] in all
the structures have been computed and discussed primarily on the basis of distance-angle scatter for better understanding of molecular
packing in cholane derivatives. In some structures, bifurcated hydrogen bonds have been observed. Solute-solvent/solvent-solute
interactions have also been investigated to understand more complicated processes that occur for biomolecules in aqueous solution.
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