| Original Article | 
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ECB. 2015; 4(10): 450-453 YTTRIUM OXIDE: A HIGHLY EFFICIENT CATALYST FOR
THE SYNTHESIS OF PYRANO[2,3-d]PYRIMIDINE
DERIVATIVES IN AQUEOUS METHANOL MEDIAD. S. Bhagat, M. V. Katariya, C. S. Patil, S. U. Deshmukh, S. U. Shisodia, S. S. Pandule, R. P. Pawar. Abstract | | | | Synthesis of pyrano[2,3-d]pyrimidine derivatives has been achieved by one-pot three component condensation reactions of various
aromatic aldehydes, malononitrile and barbituric acid in aqueous methanol using yttrium oxide (Y2O3) as a catalyst. The potential
application of Y2O3 in various synthesis increasing rapidly due to its reaction simplicity, minimum reaction time, high yields, environment
friendly procedure and low cost of chemicals. The reactants are completely soluble in 70 % aqueous methanol and afford high yield of
products.
Key words: Pyrano[2,3-d]pyrimidines; barbituric acid; aromatic aldehydes; Y2O3 catalyst
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