Aim: Diabetes mellitus is closely associated with many types of cancer including hepatocellular carcinoma (HCC). Alpha feto protein is still used as a biomarker for HCC worldwide but relation between type 2 diabetes mellitus (T2DM) and AFP is unclear. We aimed to investigate relations between AFP, T2DM and metabolic markers in this study.
Material and Methods: 208 HCC patients were enrolled to study. 50 patients had T2DM (T2DM+HCC) and 158 patients were non-diabetic (NDM+HCC). 50 healthy people enrolled to the study as control group. Serum AFP levels were compared between healthy control group, T2DM+HCC group and NDM+HCC group. Serum AFP levels were compared with age, BMI, HgbA1c, fasting plasma glucose level (FPG), serum insulin level and insulin resistance (HOMA-IR).
Results: AFP levels were higher in T2DM + HCC group patients according to healthy control group (p
Key words: Hepatocellular carcinoma; AFP; HCC; diabetes mellitus
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