2-Amino-6-(2-oxo-2H-chromen-3-yl)-4-phenylnicotino-nitrile was reacted with cyclohexanone, formic acid, acetic anhydride,
acetophenone, triethylorthoformate and hydrazine hydrate to give the corresponding pyridopyrimidine and pyridopyridine derivatives. On
the other hand, 2-amino-4-(3-chloro-phenyl)-6-(2-oxo-2H-chromen-3-yl)nicotinonitrile was cyclized by reacting it with urea, thiourea,
formamide, triethylorthoformate, hydrazine hydrate and cyclohexanone to give the corresponding cyclic pyridopyridine, pyridopyrimidine
and pyridotriazine derivatives. The potential cytotoxicity activity of compounds 7, 8, 16 and 17 was tested against breast carcinoma cell
line by SRB (Sulphorhodamine-B) assay.
Key words: 3-Acetyl coumarin, Nicotino-nitrile, Pyridopyrimidine, Naphthyridine, Antitumor.
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