Home|Journals|Articles by Year Follow on Twitter

Directory for Medical Articles
 

Open Access

Original Article



Synthesis, cytotoxicity, and promising anticancer potential of novel β-amino- and β-iminophosphonates

Vanya Koleva, Irina Yotova, Asya Dragoeva, Dobromir Enchev.

Abstract
New series of β-amino- and β-iminophosphonates were produced via a nucleophilic addition reaction of benzyl amine and 2-aminopirydine to 1,2-alkadienephosphonates. Cytotoxicity and anticancer potential of newly synthetisized compounds were investigated. Triticum aestivum L. root growth inhibition test and Allium cepa L. assay were used to assess the cytotoxic potential of phosphonates. Anticancer activity on human fibrosarcoma cell line HT 1080 was assessed. The antiproliferative effect of compounds was determined by WST-1 test, and nuclear morphology changes in cancer cells stained with Giemsa were evaluated. After treatment with β-iminophosphonate (E,Z)(3-Methyl-2-(pyridin2-ylimino)butyl)diphenylphosphine oxide (4e) proliferation/viability of cancer cells was strongly inhibited and in 65.61% of the cells signs of early apoptosis were observed. The results reported here show once again phosphonates as versatile substrates in synthetic organic chemistry, especially as fruitful starting compounds for the achievement of molecular diversity. Among tested compounds β-iminophosphonate (E,Z)(3-Methyl-2-(pyridin-2-ylimino)butyl) diphenylphosphine oxide (4e) showed anticancer activity against human fibroblastoma cell line HT 1080.

Key words: β-aminophosphonates, β-iminophosphonates, cytotoxicity, anticancer potential, apoptosis



Similar Articles

Growth differentiation factor 5: a neurotrophic factor with neuroprotective potential in Parkinson's disease.
Goulding SR, Anantha J, Collins LM, Sullivan AM, O'Keeffe GW
Neural regeneration research. 2022; 17(1): 38-44

Epsin 3 potentiates the NF‑κB signaling pathway to regulate apoptosis in breast cancer.
Wu Q, Li Q, Zhu W, Zhang X, Li H
Molecular medicine reports. 2022; 25(1):

Visible light photodegradation of 2,4-dichlorophenol using nanostructured NaBiS: Kinetics, cytotoxicity, antimicrobial and electrochemical studies of the photocatalyst.
Kumar VGD, Balaji KR, Viswanatha R, Ambika G, Roopa R, Basavaraja BM, Chennabasappa M, Kumar CRR, Chen Z, Bui XT, Santosh MS
Chemosphere. 2022; 287(Pt 2): 132174

Copper ferrite nanoparticles induced cytotoxicity and oxidative stress in Channel catfish ovary cells.
Srikanth K, Nutalapati V
Chemosphere. 2022; 287(Pt 2): 132166

Effects of selenium-containing compounds on Cu/Zn-induced neuronal cell death and potential application as therapeutic agents for neurological diseases.
Tanaka KI, Shimoda M, Kawahara M
Neural regeneration research. 2022; 17(2): 311-312


Full-text options


Latest Statistics about COVID-19
• pubstat.org


Add your Article(s) to Indexes
• citeindex.org






Covid-19 Trends and Statistics
ScopeMed.com
CiteIndex.org
CancerLine
FoodsLine
PhytoMedline
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.



ScopeMed Web Sites