In the present study we have investigated the behaviour of 5-amino-3,4-diphenylthieno[2,3-c]pyridazine-6-carbonitrile towards the
hydrazine hydrate which gives 5-amino-3,4-diphenylthieno[2,3-c]pyridazine-6-carboximidohydrazide which in turn was subjected to
subsequent reactions with benzaldehyde, acetic anhydride, acetyl acetone, formic acid, maleic anhydride and phthalic anhydride. The new
synthesized compounds were confirmed by their IR spectra, mass spectrum, 1H-NMR, and elemental analyses, and were screened for
antimicrobial activity. Several compounds showed moderate to low activity against the examined microorganisms.
Key words: Pyridazine, thienopyridazine, pyrimidothienopyridazine, synthesis, antimicrobial activity
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