Comparing The Efficiency of Gnrh Agonists On The Castration Levels Of Metastatic Prostate Cancer; Leuprolide Acetate 22.5 mg vs Goserelin Acetate 10.8mg
Short Title: Comparison of GnRH Agonists
Abstract
Objective: We aimed to evaluate the effects of using leuprolide 22.5 mg and goserelin 10.8 mg on castration levels in patients with metastatic prostate cancer.
Materials and Methods: We were evaluated 50 patients retrospectively who diagnosed metastatic prostatic cancer in our clinic between 01.06.2012-01.06.2014. There were 25 people in each group. Leuprolide 22.5 mg was given to the patients in the first group, and goserelin 10.8 mg to the patients in the second group. Patients were followed up for 2 years and testosterone, psa values checked for three months and their effects on castration were compared.
Results: The mean ages of the patients in both groups were 65 and 64 years. The mean Gleason score of the patients treated with leuprolide was 7.8, and goserelin was 7.84. Two (8%) patients treated with leuprolide and three (12%) patients treated with goserelin had testosterone levels above castration during follow-up. There were no statistically significant differences between the two groups.
Conclusions: There were no statistically significant differences between the drugs’ effect on castration period. However, patients with low Gleason score (
Key words: Anahtar Kelimeler: Prostat kanseri; Testosteron; Kastrasyon; GnRH agonisti; LHRH agonisti
Key words Prostate cancer; Testosterone, Level of castration, GnRH agonist, LHRH agonist
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