Urinary tract infections are one of the most common types of bacterial infections in humans, both in the community and in health care settings. Urinary tract infections include a range of clinical entities ranging in severity from asymptomatic infection to acute cystitis, prostatitis, pyelonephritis, and urethritis. This is one of the most common diseases encountered in medical practice today, affecting people of all ages, from newborn to geriatric age group. The bacteria most commonly implicated as agents responsible for urinary tract infections generally originate in the intestine and include Escherichia coli, Pseudomonas spp., Streptococcus spp., Proteus spp., Klebsiella spp., Staphylococcus spp., Neisseria gonorrhoaea, Chlamydia trachomatis, Candida spp. There are virulence factors of urinary pathogens that promote adhesion to mucosal surfaces and subsequent infections. The multiresistant of these enterobacteria responsible for urinary tract infections is a major public health problem. Antibiotic resistance remains a major problem especially in developing countries where hygiene conditions are still precarious and antibiotic use is often abusive and poorly controlled. The multidrug-resistant Enterobacteriaceae most implicated in urinary tract infections by ESBL and Carbapenemase production are: Klebsiella pneumoniae, Escherichia coli and Proteus spp, not to mention Acinetobacter baumanii and Pseudomonas aeruginosa, the most carbapenemase producing. The detection of ESBL and Carbapenemase production is based mainly on phenotypic and genotypic tests.
Key words: Urinary infection, Enterobacteriaceae, Virulence, Multiresistance, ESBL, Carbapenemase
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