Alteration of saliva and blood ghrelin, obestatin, leptin and weight based on adjuvant chemotherapy treatment in early-stage operated breast cancer patients
Nimet Yilmaz, Aziz Karaoglu, Kader Ugur, Meltem Yardim, Suleyman Aydin.
Aim: To evaluate the weight change and ghrelin, obestatin and leptin levels in operated early stage breast cancer patients receiving adjuvant chemotherapy.
Material and Methods: This study was conducted with 22 operated breast cancer patients (examined before and after adjuvant chemotherapy) and 33 BMI-matched two different healthy controls (of 33 healthy controls, 17 BMI-matched control was used to compare before adjuvant chemotherapy, 16 BMI-matched control was used to compare after adjuvant chemotherapy). Age, anthropometric measurements (weight, BMI, waist circumference), and blood biochemistry were recorded. Blood and salivary total ghrelin, obestatin and leptin levels are measured by using ELISA.
Results: The mean ± SD weight (67.2 ± 12.3 and 72.9 ± 11.8 kg., p
Key words: Breast cancer; adjuvant chemotherapy; ghrelin; obestatin, leptin
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